Postnatal changes in the noradrenergic system modulating hypoglossal motoneurons
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منابع مشابه
Changes during the postnatal development in physiological and anatomical characteristics of rat motoneurons studied in vitro.
The postnatal maturation of rat brainstem (oculomotor and hypoglossal nuclei) and spinal motoneurons, based on data collected from in vitro studies, is reviewed here. Membrane input resistance diminishes with age, but to a greater extent for hypoglossal than for oculomotor motoneurons. The time constant of the membrane diminishes with age in a similar fashion for both oculomotor and hypoglossal...
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In obstructive sleep apnea patients, elevated activity of the lingual muscles during wakefulness protects the upper airway against occlusions. A possibly related form of respiratory neuroplasticity is present in rats exposed to acute and chronic intermittent hypoxia (CIH). Since rats exposed to CIH have increased density of noradrenergic terminals and increased α(1)-adrenoceptor immunoreactivit...
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We reassessed and provided new insights into the findings that were obtained in our previous experiments that employed the injections of combined adrenergic, serotonergic, GABAergic, and glycinergic antagonists into the hypoglossal nucleus in order to pharmacologically abolish the depression of hypoglossal nerve activity that occurred during carbachol-induced rapid-eye-movement (REM) sleep-like...
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Hypoglossal (XII) motoneurons (MNs) contribute to diverse behaviors. Their innervation of the genioglossus muscle, a tongue protruder, plays a critical role in maintaining upper airway patency during breathing. Indeed, reduced activity in these motoneurons is implicated in sleep related disorders of breathing such as obstructive sleep apnea (OSA). The excitability of these MNs is modulated by m...
متن کاملα2-Adrenergic blockade rescues hypoglossal motor defense against obstructive sleep apnea.
Decreased noradrenergic excitation of hypoglossal motoneurons during sleep causing hypotonia of pharyngeal dilator muscles is a major contributor to the pathogenesis of obstructive sleep apnea (OSA), a widespread disease for which treatment options are limited. Previous OSA drug candidates targeting various excitatory/inhibitory receptors on hypoglossal motoneurons have proved unviable in react...
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